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Configure Script Extender settings in Settings -> Preferences -> the Script Extender tab. Install the Script Extender with a few clicks (Tools -> Download & Install the Script Extender). The Divinity Mod Manager makes this easier to install and configure with the following features: Norbyte's Script Extender (ositools) allows mods to mod the game even further, and is required by many newer mods. If a mod has a Steam Workshop page, you can open this by right clicking the mod and selecting "Open Steam Workshop Page".
Mods can also specify custom tags in their meta.lsx file.
View pending Steam Workshop mod updates and update with a few clicks. Shortcut buttons to all the various game-related folders (mods folder, workshop folder, game directory, etc). Export load order mods to zip files (including editor mods), for easier sharing of a playthrough's mods between friends. Filter mods by name and properties (author, mode, etc.). These formats will include extra data, such as the mod's steam workshop url, if any. Export your active mod order to various text formats (i.e. Save your mod load orders to external json files for sharing or backing things up. View details about each mod, including the description and dependencies. Reorganize mod load orders with a quick drag-and-drop interface. Organize your active mods for a given profile, then click the first export button (Export Load Order to Game), or click File -> Export Order to Game, to export your active load order to the game. If this fails, you can manually set the pathways in Settings -> Preferences.
Upon opening the program, pathways to the game data and exe should be automatically detected. The Divinity Mod Manager is portable, so extract it wherever you wish. Run the game once if you haven't already, so a profile and the mods folders get created. A work-in-progress mod manager for Divinity: Original Sin 2 - Definitive Edition.